Intracytoplasmic Sperm Injection (ICSI)
Intracytoplasmic sperm injection (ICSI) is a vital adjunct to in vitro fertilization that has facilitated hundreds of thousands of pregnancies around the world.
ICSI is a procedure in which a single sperm is injected directly into an egg to achieve fertilization. The resulting embryo(s) are then incubated for three or five days before transfer to the patient, or may be cryopreserved.
ICSI is commonly used to treat male factor infertility due to low sperm count, poor sperm movement or abnormally shaped sperm. ICSI is also used to fertilize oocytes that have been cryopreserved as part of a fertility preservation treatment ("egg freezing"), and in conjunction with testicular sperm extraction (TESE) and PGD/PGS.
Dr. Gianpiero Palermo, the Blavatnik Professor of Reproductive Medicine and Director of CRM's Andrology Laboratory, in 1992 was the first person to perform and describe ICSI. Dr. Palermo and his staff continue to refine the ICSI procedure in their ongoing research.